Nikolay Didenko started making music professionally in early childhood. In 1982, at the age of seven, he was admitted to the Sveshnikov Moscow Choral College, and in the same year he enrolled at the Stasov Music School (violin class). In 1996, he continued his studies at the Popov Academy of Choral Art. In 2003, he completed his graduate studies there (class of Prof. Dmitri Vdovin).
From 2002 to 2003, he was a leading soloist at the Kolobov Novaya Opera Theatre of Moscow. Since 2003, his international career has started to develop rapidly.
From 2003 to 2005, he was a soloist at the Houston Grand Opera Studio (USA). Since 2004, Nikolay Didenko has been represented by the top international agency Askonas Holt (UK). Since 2003, he has been making his debut at opera houses and concert halls in New York, Washington, Houston, Paris, London, Berlin, Barcelona, Madrid, Copenhagen, Cologne, Warsaw, Salzburg, St Petersburg, Moscow, among other places.
He has performed opera parts and participated in concerts with famous singers of our time: Ramon Vargas, Renee Fleming, Nikolai Ghiaurov, Mirella Freni, Edita Gruberova, Federica Von Stade, Vladimir Galuzin, Maria Guleghina, June Anderson, Bryn Terfel, Matti Salminen, Massimo Giordano, Laura Claycomb, etc.; he has worked with such conductors as Antoniello Allemandi, Patrick Summers, Edoardo Muller, Nello Santi, Enrique Mazzola, Marco Armigliato, Valery Gergiev, Vladimir Fedoseev, Vladimir Spivakov, Rudolf Barshai, Vasily Sinaisky, Alexander Anisimov, Vladimir Yurovsky, Mikhail Pletnev, Gennady Rozhdestvensky, etc.
Since 2013, he has performed at the Bolshoi Theatre as a guest soloist.
In 2017, the recording of K. Penderecki’s composition Dies Illa with the participation of Nikolay Didenko won a Grammy Award.
Since 2005, Nikolay Didenko has been the artistic director of the White Steamer charitable program aimed at the creative development and rehabilitation of musically gifted children with disabilities, orphans, children from socially disadvantaged, single-parent, large, and low-income families. Since 2017, he has been the President of the White Steamer Foundation for Supporting Creatively Gifted Children and Youth.
In 2017, Nikolay Didenko joined the presidium of the All-Russian Choral Society.